Neuste Forschungsergebnisse


  1. Vaupel P. (Editor) Water-filtered Infrared A (wIRA) Irradiation - From Research to Clinical Settings. Springer International Publishing. 2022. Open Access [SpringerLINK]

  2. Guevara Solarte DL, Rau SJ, Hellwig E, Vach K, Al-Ahmad A. Antimicrobial Behavior and Cytotoxicity of Indocyanine Green in Combination with Visible Light and Water-Filtered Infrared A Radiation against Periodontal Bacteria and Subgingival Biofilm. Biomedicines 2022, 10, 956. (DOI: 10.3390/biomedicines10050956) [LINK]




  3. Chrubasik-Hausmann S, Hellwig E, Müller M, Al-Ahmad A. Antimicrobial Photodynamic Treatment with Mother Juices and Their Single Compounds as Photosensitizers. Nutrients 2021; 13: 710 (DOI: 10.3390/nu13030710). [LINK]

  4. Notter M, Thomsen AR, Grosu A-L, Vaupel P. Recommendation of Regional Hyperthermia in the Treatment of Breast Cancer. Integr Cancer Ther 2021; 20:1534735420988606 (DOI: 10.1177/1534735420988606). [LINK]

  5. Notter M, Stutz E, Thomsen AR, Vaupel P. Radiation-Associated Angiosarcoma of the Breast and Chest Wall Treated with Thermography-Controlled, Contactless wIRA-Hyperthermia and Hypofractionated Re-Irradiation. Cancers (Basel). 2021;13(15):3911. Published 2021 Aug 3. [LINK]

  6. Klemm Ph, Aykara I, Eichelmann M, Neumann E, Frommer K, Lange U. Treatment of back pain in active axial spondyloarthritis with serial locoregional water-filtered infrared A radiation: A randomized controlled trial. J Back Musculoskelet Rehabil 2021 Sep 24 (DOI: 10.3233/BMR-210068) [LINK]

  7. Frohns A, Stojanovic M, Barisani-Asenbauer T, Kuratli J; Borel N, Inic-Kanada A. Effects of water-filtered infrared A and visible light (wIRA/VIS) radiation on heat- and stress-responsive proteins in the retina and cornea of guinea pigs. J Photochem Photobiol B: Biology 2021, 224:112306. (DOI: 10.1016/j.jphotobiol.2021.112306). [LINK]

  8. Peikert SA, Fischer A, Kruse AB, Al-Ahmad A, Woelber JP, Vach K, Braun A, Ratka-Krüger P. Adjuvant Transgingival Therapy with Visible Light Plus Water-Filtered Infrared-A (VIS + wIRA) in Periodontal Therapy-A Randomized, Controlled, Stratified, Double-Blinded Clinical Trial. Antibiotics 2021, 10, 251. (DOI:10.3390/antibiotics10030251). [LINK]

  9. Wiegand C, Hipler U-Ch, Elsner P, Tittelbach J. Keratinocyte and Fibroblast Wound Healing In Vitro Is Repressed by Non-Optimal Conditions but the Reparative Potential Can Be Improved by Water-Filtered Infrared A. Biomedicines 2021; 9: 1802 (DOI: 10.3390/biomedicines9121802). [LINK]

  10. Nitsche M, Dunst J, Krug D, Meyer R, Herman RM. Strahlentherapie mit Hyperthermie beim Mammakarzinom. Der Gynäkologe 2021/06/25. [PDF]

  11. Schuester L, Liebl M.E, Stroux A, Reißhauer A. Wassergefiltertes Infrarot A (wIRA) bei Gonarthrose – eine prospektive randomisierte kontrollierte Studie. Water-Filtered Infrared A (wIRA) Treatment of Knee Osteoarthritis – A Prospective Randomized Controlled Study. Phys Med Rehab Kuror 2021, 22 Feb online. (DOI: 10.1055/a-1349-1482) [PDF]

  12. Karygianni L, Ruf S, Hellwig E, Follo M, Vach K, Al-Ahmad A. Karygianni L, Ruf S, Hellwig E, Follo M, Vach K, Al-Ahmad A. Antimicrobial Photoinactivation of In Situ Oral Biofilms by Visible Light Plus Water-Filtered Infrared A and Tetrahydroporphyrin-tetratosylate (THPTS). Microorganisms 2021; 9:145 (DOI: 10.3390/microorganisms9010145). [LINK]

  13. Zawawi WFAWM, Hibma HM, Salim MI, Jemon K. Hyperthermia by near infrared radiation induced immune cells, activation and infiltration in breast tumor. Sci Rep 2021; 11(1):10278 (DOI: 10.1038/s41598-021-89740-0) [LINK]

  14. Priester MI, Curto S, van Rhoon GC, Ten Hagen TLM. External Basic Hyperthermia Devices for Preclinical Studies in Small Animals. Cancers 2021; 13(18):4628 (DOI: 10.3390/cancers13184628). [LINK]

  15. Zschaeck S, Weingärtner J, Ghadjar P, Wust P, Mehrhof F, Kalinauskaite G, Ehrhardt V, Hartmann V, Tinhofer I, Heiland M, Coordes A, Kofla G, Budach V, Stromberger C, Beck M. Fever range whole body hyperthermia for re-irradiation of head and neck squamous cell carcinomas: Final results of a prospective study. Oral Oncology 2021 May; 116:105240. [LINK]




  16. Borel N, Sauer-Durand AM, Hartel M, Kuratli J, Vaupel P, Scherr N, Pluschke G. wIRA: hyperthermia as a treatment option for intracellular bacteria, with special focus on Chlamydiae and Mycobacteria. Int J Hyperthermia. 2020;37(1):373-383.

  17. Burchard T, Karygianni L, Hellwig E, Wittmer A, Al-Ahmad A. Microbial Composition of Oral Biofilms after Visible Light and Water-filtered Infrared A radiation (VIS+wIRA) in Combination with Indocyanine Green (ICG) as Photosensitizer. Antibiotics (Basel). 2020 Aug 23;9(9): E532. [PDF]  

  18. Inic-Kanada A, Stojanovic M, Miljkovic R, Stein E, Filipovic A, Frohns A, Zöller N, Kuratli J, Barisani-Asenbauer T, Borel N. Water-filtered Infrared A and visible light (wIRA/VIS) treatment reduces Chlamydia caviae-induced ocular inflammation and infectious load in a Guinea pig model of inclusion conjunctivitis. J Photochem Photobiol B. 2020 Jul 5;209:111953.

  19. Klemm P, Eichelmann M, Aykara I, Hudowenz O, Dischereit G, Lange U. Serial locally applied water-filtered infrared a radiation in axial spondyloarthritis - a randomized controlled trial.  Int J Hyperthermia. 2020;37(1):965-970. [PDF]

  20. Kok HP, Cressman ENK, Ceelen W, Brace CL, Ivkov R, Grüll H, ter Haar G, Wust P, Creeze J. Heating technology for malignant tumors: a review, Int J Hyperthermia 2020; 37/1:711-741 [PDF]

  21. Notter M, Thomsen AR, Nitsche M, Hermann RM, Wolff HA, Habl G, Münch K, Grosu AL, Vaupel P. Combined wIRA-Hyperthermia and Hypofractionated Re-Irradiation in the Treatment of Locally Recurrent Breast Cancer: Evaluation of Therapeutic Outcome Based on a Novel Size Classification. Cancers (Basel). 2020 Mar 6;12(3):606. [PDF]

  22. Piazena H, Müller W, Vaupel P. wIRA-heating of piglet skin and subcutis in vivo: proof of accordance with ESHO criteria for superficial hyperthermia. Int J Hyperthermia. 2020;37(1):887-896.

  23. Rühle A, Thomsen A, Saffrich R, Voglstätter M, Bieber B, Sprave T, Wuchter P, Vaupel P, Huber PE, Grosu A-L and Nicolay NH. Multipotent mesenchymal stromal cells are sensitive to thermic stress - potential implications for therapeutic hyperthermia. Int J Hyperthermia 2020; 37/1:430-441 [PDF]

  24. Scheel-Sailer A, Aliyev N, Jud D, Annaheim S, Harder Y, Krebs J, Wildisen A, Wettstein R. Changes in skin-physiology after local heat application using two different methods in individuals with complete paraplegia: a feasibility and safty trial. Spinal Cord. 2020 Jun;58(6):667-674.

  25. Thomsen AR, Vaupel P, Grosu A-L, Notter M. Correspondence: Hyperthermia Plus Re-Irradiation in the Management of Unresectable Locoregional Recurrence of Breast Cancer in Previously Irradiated Sites. J Clin Oncol 2020; 38:3576-3577 [PDF]






  26. Al-Ahmad A, Burchard T, Karygianni L, Follo M, Hellwig E. Photoinactivation of oral biofilms using visible light and water-filtered infrared A (vis+wIRA) in combination with indocyanine green (ICG). 8th Congress of European Microbiologists, 7-11 July 2019 Glasgow, Scotland.

  27. Aljasir A, Pierson T, Hoffmann G, Menke H. Management of donor site infections in split-thickness skin graft with water-filtered infrared-A (wIRA). GMS Interdiscip Plast Reconstr Surg DGPW. 2018 Jun 12;7:Doc03. [PDF]

  28. Brazaitis M, Eimantas N, Baranauskiene N, Kilikeviciene S, Vitkauskiene A, Daniuseviciute L. Effects of severe whole-body hyperthermia on ovarian hormone and extracellular Hsp72 responses in young adult women. Int J Hyperthermia. 2019;36(1):660-665. [PDF]

  29. Burchard T, Karygianni L, Hellwig E, Follo M, Wrbas T, Wittmer A, Vach K, Al-Ahmad A. Inactivation of oral biofilms using visible light and water-filtered infrared A radiation and indocyanine green. Future Medicinal Chemistry. 2019 in print. [PDF]

  30. Chang M, Wang M, Shu M, Zhao Y, Ding B, Huang S, Hou Z, Han G, Lin J. Enhanced photoconversion performance of NdVO4/Au nanocrystals for photothermal/photoacoustic imaging guided and near infrared light-triggered anticancer phototherapy. Acta Biomater. 2019 Aug 19.

  31. Chen Y, Ren J, Tian D, Li Y, Jiang H, Zhu J. Polymer-Upconverting Nanoparticle Hybrid Micelles for Enhanced Synergistic Chemo-Photodynamic Therapy: Effects of Emission-Absorption Spectral Match. Biomacromolecules. 2019 Sep 5.

  32. Chiu WT, Tran TV, Pan SC, Huang HK, Chen YC, Wong TW. Cystic Fibrosis Transmembrane Conductance Regulator: A Possible New Target for Photodynamic Therapy Enhances Wound Healing. Adv Wound Care (New Rochelle). 2019 Oct 1;8(10):476-486. [PDF]

  33. Cieplik F, Deng D, Crielaard W, Buchalla W, Hellwig E, Al-Ahmad A, Maisch T. Antimicrobial photodynamic therapy - what we know and what we don't. Crit Rev Microbiol. 2018 Sep;44(5):571-589. [PDF]

  34. de Gálvez MV, Aguilera J, Sánchez-Roldán C, Herrera-Acosta E, Herrera-Ceballos E. Water-Filtered Infrared Radiation Decreases the Generation of Photodermatoses Dependent on Ultraviolet and Visible Radiation. Photochem Photobiol. 2019 May;95(3):874-878.

  35. Eichelmann M, Klemm P, Dischereit G, Lange U. Additive serielle lokale wassergefilterte Infrarot-A-Strahlung (asl-wIRAS) ist wirkungsvoll bei Spondyloarthritiden im Rahmen einer multimodalen rheumatologischen Komplexbehandlung (MRKB) 124. Jahreskongress der Deutschen Gesellschaft für Physikalische und Rehabilitive Medizin (DGPRM), München 12.-14. September 2019. [PDF]

  36. Garai A, Gandhi A, Ramu V, Raza MK, Kondaiah P, Chakravarty AR. Photochemotherapy of Infrared Active BODIPY-Appended Iron(III) Catecholates for in Vivo Tumor Growth Inhibition. ACS Omega. 2018 Aug 17;3(8):9333-9338. [PDF]

  37. Hale MW, Lukkes JL, Dady KF, Kelly KJ, Paul ED, Smith DG, Heinze JD, Raison CL, Lowry CA. Interactions between whole-body heating and citalopram on body temperature, antidepressant-like behaviour, and neurochemistry in adolescent male rats. Behav Brain Res. 2019 Feb 1;359:428-439.

  38. Hanusch KU, Janssen CW. The impact of whole-body hyperthermia interventions on mood and depression - are we ready for recommendations for clinical application? Int J Hyperthermia. 2019;36(1):573-581. [PDF]

  39. Kang ES, Lee TH, Liu Y, Han KH, Lee WK, Yoon I. Graphene Oxide Nanoparticles Having Long Wavelength Absorbing Chlorins for Highly-Enhanced Photodynamic Therapy with Reduced Dark Toxicity. Int J Mol Sci. 2019 Sep 5;20(18). [PDF]

  40. Kercher EM, Nath S, Rizvi I, Spring BQ. Cancer Cell-targeted and Activatable Photoimmunotherapy Spares T Cells in a 3D Co-culture Model. Photochem Photobiol. 2019 Aug 19.

  41. König A, Missalla S, Valesky EM, Bernd A, Kaufmann R, Kippenberger S, Zöller NN. Effect of near-infrared photobiomodulation therapy in a cellular wound healing model. Photodermatol Photoimmunol Photomed. 2018 Apr 26.

  42. Kuratli J, Borel N. Perspective:Water-Filtered Infrared-A-Radiation (wIRA) - Novel Treatment Options for Chlamydial Infections? Front Microbiol. 2019 May 10;10:1053. [PDF]

  43. Kuratli J, Pesch T, Marti H, Leonard CA, Blenn C, Torgerson P, Borel N. Water Filtered Infrared A and Visible Light (wIRA/VIS) Irradiation Reduces Chlamydia trachomatis Infectivity Independent of Targeted Cytokine Inhibition. Front Microbiol. 2018 Nov 15;9:2757. [PDF]

  44. Lassche G, Crezee J, Van Herpen CML. Whole-body hyperthermia in combination with systemic therapy in advanced solid malignancies. Crit Rev Oncol Hematol. 2019 Jul;139:67-74.

  45. Li Q, Hou M, Ren J, Lu S, Xu Z, Li CM, Kang Y, Xue P. Co-delivery of chlorin e6 and doxorubicin using PEGylated hollow nanocapsules for 'all-in-one' tumor theranostics. Nanomedicine (Lond). 2019 Aug 15.

  46. Li W, Yang J, Luo L, Jiang M, Qin B, Yin H, Zhu C, Yuan X, Zhang J, Luo Z, Du Y, Li Q, Lou Y, Qiu Y, You J. Targeting photodynamic and photothermal therapy to the endoplasmic reticulum enhances immunogenic cancer cell death. Nat Commun. 2019 Jul 26;10(1):3349. [PDF]

  47. Meerovich GA, Akhlyustina EV, Tiganova IG, Lukyanets EA, Makarova EA, Tolordava ER, Yuzhakova OA, Romanishkin ID, Philipova NI, Zhizhimova YS, Romanova YM, Loschenov VB, Gintsburg AL. Novel Polycationic Photosensitizers for Antibacterial Photodynamic Therapy. Adv Exp Med Biol. 2019 Aug 25.

  48. Meesaragandla B, Sarkar D, Mahalingam V. Methylene Blue-Loaded Upconverting Hydrogel Nanocomposite: Potential Material for Near-Infrared Light-Triggered Photodynamic Therapy Application. ACS Omega. 2019 Feb 13;4(2):3169-3177. [PDF]

  49. Meijer MS, Talens VS, Hilbers MF, Kieltyka RE, Brouwer AM, Natile MM, Bonnet S. NIR-Light-Driven Generation of Reactive Oxygen Species Using Ru(II)-Decorated Lipid-Encapsulated Upconverting Nanoparticles. Langmuir. 2019 Sep 3.

  50. Notter M und Vaupel P. Combined wIRA-hyperthermia and repeat re-irradiation (re-re-RT) in the management of re-recurrences of locally recurrent breast cancer. ESHO 2019, 33rd Annual Meeting in Warscawa, 22-25 May 2019.

  51. Notter M, Piazena H, Vaupel P. Hypofractionated re-irradiation of large-sized recurrent breast cancer with thermography-controlled, contact-free water-filtered infra-red-A hyperthermia: a retrospective study of 73 patients. Int J Hyperthermia. 2017 Mar;33(2):227-236. [PDF]

  52. Piazena H, Müller W, Pendl W, von Ah S, Cap VH, Hug PJ, Sidler X, Pluschke G, Vaupel P. Thermal field formation during wIRA-hyperthermia: temperature measurements in skin and subcutis of piglets as a basis for thermotherapy of superficial tumors and local skin infections caused by thermosensitive microbial pathogens. Int J Hyperthermia. 2019;36(1):938-952 [PDF]

  53. Stange R, Heselhaus S. Förderung der Wundheilung mit wassergefiltertem Infrarot A – state oft the art. WUNDmanagement 2018:12- Suppl. WUKO 2018 S. 64 [PDF]

  54. Stange R. Nicht-onkologische Behandlungsmöglichkeiten mit wassergefiltertem Infrarot A (wIRA). In: Bundesanstalt für Arbeitsschutz und Arbeitsmedizin (BAuA)  (Hg). Kongressband Licht und Gesundheit 3./4. April 2019. [PDF]

  55. Tanaka Y, Nakayama J. Upregulated expression of La ribonucleoprotein domain family member 6 and collagen type I gene following water-filtered broad-spectrum near-infrared irradiation in a 3-dimensional human epidermal tissue culture model as revealed by microarray analysis. Australas J Dermatol. 2018 May;59(2):e87-e92.

  56. Tang M, Zhu X, Zhang Y, Zhang Z, Zhang Z, Mei Q, Zhang J, Wu M, Liu J, Zhang Y. Near-Infrared Excited Orthogonal Emissive Upconversion Nanoparticles for Imaging-Guided On-Demand Therapy. ACS Nano. 2019 Aug 26.

  57. Vaupel P, Piazena H, Müller W, Notter M. Biophysical and photobiological basics of water-filtered infrared-A hyperthermia of superficial tumors. Int J Hyperthermia. 2018;35(1):26-36. [PDF]

  58. Vollmer A, Al-Ahmad A, Argyropoulou A, Thurnheer T, Hellwig E, Attin T, Vach K, Wittmer A, Ferguson K, Skaltsounis AL, Karygianni L. Antimicrobial Photoinactivation Using Visible Light Plus Water-Filtered Infrared-A (VIS+wIRA) and Hypericum Perforatum Modifies In Situ Oral Biofilms. Sci Rep. 2019 Dec 30;9(1):20325. [PDF]

  59. Xu J, Deng Y, Yu CY, Gao ZM, Yang XR, Zhang Q, Zhang L. Efficacy of wIRA in the treatment of sacroiliitis in male patients with ankylosing spondylitis and its effect on serum VEGF levels. J Orthop Surg Res. 2019 Sep 18;14(1):313. [PDF]

  60. Xue Y, Li J, Yang G, Liu Z, Zhou H, Zhang W. Multistep Consolidated Phototherapy Mediated by a NIR-Activated Photosensitizer. ACS Appl Mater Interfaces. 2019 Sep 4.

  61. Yang B, Liu H, Yang H, Chen W, Wu J, Feng X, Tong R, Yu H, Chen Y, Lv Z, Sun W, He B, Wu J, Yu G, Mao Z, Zheng S. Combinatorial photochemotherapy on liver cancer stem cells with organoplatinum(ii) metallacage-based nanoparticles. J Mater Chem B. 2019 Aug 29.

  62. Zhou P, Pan L, Deng G, Zhou Z, Zhao H, Peng C, Yang S. Fe@Fe3Ge2 nanoparticles for MR imaging-guided NIR-driven photodynamic therapy in vivo. J Mater Chem B. 2019 Aug 30.